Dmbt1 Polyclonal Antibody for Mouse(Mus musculus) | EIAab.comDmbt1 Polyclonal Antibody for Mouse(Mus musculus)

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Dmbt1 (Gene name),

Deleted in malignant brain tumors 1 protein (Protein name ), DMBT1_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Dmbt1(Crpd);

Protein name:

Deleted in malignant brain tumors 1 protein;

Alternative:

CRP-ductin;Apactin;Hensin;Glycoprotein 300(gp300);Vomeroglandin;Mucin-like glycoprotein(Muclin);p80;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Interacts with LGALS3. Binds SPAR in a calcium-dependent manner (By similarity). Binds SFTPD in a calcium-dependent manner.

Function:

May play roles in mucosal defense system and cellular immune defense. May play a role in liver regeneration. May be an important factor in fate decision and differentiation of transit-amplifying ductular (oval) cells within the hepatic lineage. May function as a binding protein in saliva for the regulation of taste sensation. May play a role as an opsonin receptor for SFTPD and SPAR in macrophage tissues throughout the body, including epithelial cells lining the gastrointestinal tract (By similarity). Required for terminal differentiation of columnar epithelial cells during early embryogenesis. Displays a broad calcium-dependent binding spectrum against both Gram-positive and Gram-negative bacteria, suggesting a role in defense against bacterial pathogens. Binds to a range of poly-sulfated and poly-phosphorylated ligands which may explain its broad bacterial-binding specificity. Inhibits cytoinvasion of S.enterica. Associates with the actin cytoskeleton and is involved in its remodeling during regulated exocytosis. Interacts with pancreatic zymogens in a pH-dependent manner and may act as a Golgi cargo receptor in the regulated secretory pathway of the pancreatic acinar cell.

Subcellular Location:

Secreted Cytoplasmic vesicle secretory vesicle membrane Single-pass membrane protein Lumenal side Localized to the lumenal aspect of crypt cells in the small intestine. In the colon, seen in the lumenal aspect of surface epithelial cells. Formed in the ducts of von Ebner gland and released into the fluid bathing the taste buds contained in the taste papillae. In the CFTR knockout mouse, enhanced on the acinar luminar surface.

Protein Attributes:

Sequence length:

2085

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AIFGGVFLAM | VLAVAAFTLG | RRTHIDRGQP | PSTKL

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

Q60997

KEGG:

mmu:12945

SMR:

Q60997

Pfam:

PF00431

UniGene:

Mm.4138

Uniprot:

Q60997

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ELISA Kit for Mouse Deleted in malignant brain tumors 1 protein

Cat.:

E15081h

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Packing:

96T

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ELISA Kit for Mouse Deleted in malignant brain tumors 1 protein

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ELISA Kit for Mouse Deleted in malignant brain tumors 1 protein

MSDS:

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ELISA Kit for Mouse Deleted in malignant brain tumors 1 protein

MSDS:

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ELISA Kit for Mouse Deleted in malignant brain tumors 1 protein

MSDS:

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CLIA Kit for Mouse Deleted in malignant brain tumors 1 protein

Cat.:

U15081h

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MSDS:

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Packing:

96T

CLIA Kit for Mouse Deleted in malignant brain tumors 1 protein

MSDS:

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CLIA Kit for Mouse Deleted in malignant brain tumors 1 protein

MSDS:

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CLIA Kit for Mouse Deleted in malignant brain tumors 1 protein

MSDS:

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CLIA Kit for Mouse Deleted in malignant brain tumors 1 protein

MSDS:

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Polyclonal Antibody for Mouse Deleted in malignant brain tumors 1 protein

Monoclonal Antibody for Mouse Deleted in malignant brain tumors 1 protein

Protein for Mouse Deleted in malignant brain tumors 1 protein

R&D Technical Data

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Precision

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Recovery

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Linearity

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References

1.

"CRP-ductin: a gene expressed in intestinal crypts and in pancreatic and hepatic ducts."
Cheng H. , Bjerknes M. , Chen H.
Anat. Rec.244:327-343(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2);FUNCTION IN EPITHELIAL DIFFERENTIATION;ALTERNATIVE SPLICING;TISSUE SPECIFICITY;SUBCELLULAR LOCATION
strain: BALB/c.
tissue: Jejunal epithelium.
2.

"Vomeroglandin/CRP-ductin is strongly expressed in the glands associated with the mouse vomeronasal organ: identification and characterization of mouse vomeroglandin."
Matsushita F. , Miyawaki A. , Mikoshiba K.
Biochem. Biophys. Res. Commun.268:275-281(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3);PROTEIN SEQUENCE OF 22-40 AND 1942-1957;TISSUE SPECIFICITY
strain: ddY.
3.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4)
strain: FVB/N.
tissue: Colon.
4.

"Characterization of the major sulfated protein of mouse pancreatic acinar cells: a high molecular weight peripheral membrane glycoprotein of zymogen granules."
De Lisle R.C.
J. Cell. Biochem.56:385-396(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;GLYCOSYLATION
5.

"Increased expression of sulfated gp300 and acinar tissue pathology in pancreas of CFTR(-/-) mice."
De Lisle R.C.
Am. J. Physiol.268:G717-G723(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
6.

"Expression of sulfated gp300 and changes in glycosylation during pancreatic development."
De Lisle R.C. , Isom K.S.
J. Histochem. Cytochem.44:57-66(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DEVELOPMENTAL STAGE;GLYCOSYLATION
7.

"Muclin expression in the cystic fibrosis transmembrane conductance regulator knockout mouse."
De Lisle R.C. , Petitt M. , Huff J. , Isom K.S. , Agbas A.
Gastroenterology113:521-532(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;TISSUE SPECIFICITY
8.

"Developmental expression of a mucinlike glycoprotein (MUCLIN) in pancreas and small intestine of CF mice."
De Lisle R.C. , Petitt M. , Isom K.S. , Ziemer D.
Am. J. Physiol.275:G219-G227(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
9.

"Processing of pro-muclin and divergent trafficking of its products to zymogen granules and the apical plasma membrane of pancreatic acinar cells."
De Lisle R.C. , Ziemer D.
Eur. J. Cell Biol.79:892-904(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
10.

"Role of sulfated O-linked glycoproteins in zymogen granule formation."
De Lisle R.C.
J. Cell Sci.115:2941-2952(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
11.

"CRP-ductin, the mouse homologue of gp-340/deleted in malignant brain tumors 1 (DMBT1), binds gram-positive and gram-negative bacteria and interacts with lung surfactant protein D."
Madsen J. , Tornoee I. , Nielsen O. , Lausen M. , Krebs I. , Mollenhauer J. , Kollender G. , Poustka A. , Skjodt K. , Holmskov U.
Eur. J. Immunol.33:2327-2336(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH SFTPD;TISSUE SPECIFICITY
12.

"Apactin is involved in remodeling of the actin cytoskeleton during regulated exocytosis."
Tandon C. , De Lisle R.C.
Eur. J. Cell Biol.83:79-89(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;PHOSPHORYLATION AT THR-2073 AND SER-2082;MUTAGENESIS OF THR-2073 AND SER-2082
13.

"Binding of the Golgi sorting receptor muclin to pancreatic zymogens through sulfated O-linked oligosaccharides."
Boulatnikov I. , De Lisle R.C.
J. Biol. Chem.279:40918-40926(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
14.

"Conversion of ES cells to columnar epithelia by hensin and to squamous epithelia by laminin."
Takito J. , Al-Awqati Q.
J. Cell Biol.166:1093-1102(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE;FUNCTION;DEVELOPMENTAL STAGE
15.

"Expression of pro-muclin in pancreatic AR42J cells induces functional regulated secretory granules."
De Lisle R.C. , Norkina O. , Roach E. , Ziemer D.
Am. J. Physiol.289:C1169-C1178(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
16.

"DMBT1 confers mucosal protection in vivo and a deletion variant is associated with Crohn's disease."
Renner M. , Bergmann G. , Krebs I. , End C. , Lyer S. , Hilberg F. , Helmke B. , Gassler N. , Autschbach F. , Bikker F. , Strobel-Freidekind O. , Gronert-Sum S. , Benner A. , Blaich S. , Wittig R. , Hudler M. , Ligtenberg A.J. , Madsen J. , more...
Gastroenterology133:1499-1509(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE
17.

"Effects of muclin (Dmbt1) deficiency on the gastrointestinal system."
De Lisle R.C. , Xu W. , Roe B.A. , Ziemer D.
Am. J. Physiol.294:G717-G727(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE

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